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Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief.

Availability

The indicated adult dose for muscle spasm is 25 mg to 150 mg per day, increased if necessary to a maximum of 300 mg per day, in divided doses. Tetrazepam is not generally recommended for use in children, except on the advice of a specialist.

Tetrazepam is only available in one strength and formulation, 50 mg tablets. The benzodiazepine equivalent of tetrazepam is approximately 100 mg of tetrazepam = 10 mg of diazepam.

C16-H17-Cl-N2-O

Molecular Weight

289

Therapeutic Category

Muscle relaxant

Chemical Name

2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-metyl-

Foreign Names

• Tetrazepamum (Latin)
• Tetrazepam (German)
• Tétrazépam (French)
• Tetrazepam (Spanish)

Generic Names

• Tetrazepam (OS: BAN)
• Tétrazépam (OS: DCF)
• CB 4261 (IS)
• Tetrazepam (PH: BP 2018, Ph. Eur. 9)
• Tétrazépam (PH: Ph. Eur. 9)
• Tetrazepamum (PH: Ph. Eur. 9)

side effects of tetrazepam

Allergic reactions to tetrazepam occasionally occur involving the skin.

Allergic reactions can develop to tetrazepam and it is considered to be a potential allergen. Drug rash and drug-induced eosinophilia with systemic symptoms is a known complication of tetrazepam exposure. These hypersensitive allergic reactions can be of the delayed type.

Toxic epidermal necrolysis has occurred from the use of tetrazepam. Including at least one reported death. Stevens–Johnson syndrome and erythema multiforme has been reported from use of tetrazepam. Cross-reactivity with other benzodiazepines does not typically occur in such patients. Exanthema and eczema may occur. The lack of cross-reactivity with other benzodiazepines is believed to be due to the molecular structure of tetrazepam. Photodermatitis and phototoxicity have also been reported. Occupational contact allergy can also develop from regularly handling tetrazepam. Airborne contact dermatitis can also occur as an allergy which can develop from occupational exposure.

Oral testing can also be used. Skin prick tests are not always accurate and may produce false negatives.

Drowsiness is a common side effect of tetrazepam. A reduction in muscle force can occur.

Myasthenia gravis, a condition characterised by severe muscle weakness is another potential adverse effect from tetrazepam.

Cardiovascular and respiratory adverse effects can occur with tetrazepam similar to other benzodiazepines.